0001104659-04-009105 Sample Contracts

ELAN CORPORATION PLC ELAN PHARMA INTERNATIONAL LIMITED ELAN INTERNATIONAL SERVICES, LTD ELAN PHARMACEUTICALS, INC. MONKSLAND HOLDINGS BV AND AMARIN CORPORATION PLC
Settlement Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations • Delaware
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Date 25TH FEBRUARY 2004 AMARIN CORPORATION PLC, AND VALEANT PHARMACEUTICALS INTERNATIONAL, DEVELOPMENT AGREEMENT
Development Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations • California
DEED OF VARIATION NO. 2 RELATING TO AMENDED AND RESTATED DISTRIBUTION, MARKETING AND OPTION AGREEMENT DATED 28 SEPTEMBER 2001 (PERMAX®)
Distribution Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations
AMENDMENT AGREEMENT NO. 1 RELATING TO AMENDED AND RESTATED ASSET PURCHASE AGREEMENT DATED AS OF 29 SEPTEMBER 1999 (THE “CARNRICK LOAN”)
Amendment Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations
ASSET PURCHASE AGREEMENT BY AND BETWEEN VALEANT PHARMACEUTICALS INTERNATIONAL, AS BUYER AND AMARIN CORPORATION PLC AND AMARIN PHARMACEUTICALS COMPANY LIMITED, AS SELLERS DATED FEBRUARY , 2004
Asset Purchase Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations • California

This Asset Purchase Agreement (as amended from time to time, this “Agreement”) is made and entered into this day of February, 2004, by and between Valeant Pharmaceuticals International, a Delaware corporation (“Buyer”), and Amarin Corporation plc, a public limited company incorporated in England and Wales (“Amarin”) and Amarin Pharmaceuticals Company Limited, a limited company incorporated in England and Wales (“APCL”) (Amarin and APCL being hereinafter from time to time referred to collectively as the “Sellers”).

DEED OF VARIATION NO. 4 RELATING TO LOAN AGREEMENT DATED 28 SEPTEMBER 2001 AS AMENDED
Loan Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations
Dated 28 October 2003 between
Share Subscription and Purchase Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations
Date: 23 December 2003 ELAN CORPORATION, PLC. ELAN PHARMA INTERNATIONAL LIMITED ELAN INTERNATIONAL SERVICES, LTD. ELAN PHARMACEUTICALS, INC. MONKSLAND HOLDINGS BV AND AMARIN CORPORATION PLC. AMENDMENT AGREEMENT
Amendment Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations • Delaware

• Amended and Restated Asset Purchase Agreement (Carnrick products), 29 September 1999 as amended and together with Amendment Agreement, 4 August 2003

AMENDED AND RESTATED OPTION AGREEMENT (ZELAPAR™)
Option Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations • Delaware

NOW, THEREFORE, in consideration of the foregoing and the mutual covenants set forth below, the parties hereby agree as follows:

AMENDMENT NO. 1 TO ASSET PURCHASE AGREEMENT
Asset Purchase Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations • California

This Amendment No. 1 to the Asset Purchase Agreement (the “Amendment”) is made and entered into this 25th day of February, 2004, by and between Valeant Pharmaceuticals International, a Delaware corporation (“Buyer”), and Amarin Corporation plc, a public limited company incorporated in England and Wales (“Amarin”) and Amarin Pharmaceuticals Company Limited, a limited company incorporated in England and Wales (“APCL”) (Amarin and APCL being hereinafter from time to time referred to collectively as the “Sellers”).

Amended and Restated Option Agreement between Elan Pharma International Limited (“Elan”) and Amarin Corporation plc. (“Amarin”), 4 August 2003 (the “Zelapar Agreement”)
Option Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations • London

This letter sets out the terms on which Elan and Amarin have agreed to amend the Zelapar Agreement and to conduct their respective business in relation to Zelapar (the “Product”).

As Trustee DEBENTURE AMENDMENT AGREEMENT
Debenture Amendment Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations
Date: 23 December 2003 AMARIN CORPORATION PLC. AND ELAN PHARMACEUTICALS, INC. BRIDGING LOAN AGREEMENT
Bridging Loan Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations • England
As Trustee DEBENTURE AMENDMENT AGREEMENT NO. 2
Debenture Amendment Agreement • March 31st, 2004 • Amarin Corp Plc\uk • Pharmaceutical preparations
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