0001104659-04-016338 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • June 7th, 2004 • Epix Medical Inc • In vitro & in vivo diagnostic substances • New York

SG COWEN & CO., LLC NEEDHAM & COMPANY, INC. WELLS FARGO SECURITIES, LLC WR HAMBRECHT + CO, LLC As representatives of the Initial Purchasers

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EPIX MEDICAL, INC.
Indenture • June 7th, 2004 • Epix Medical Inc • In vitro & in vivo diagnostic substances • New York

INDENTURE, dated as of June 7, 2004, between EPIX MEDICAL, INC., a corporation duly organized and existing under the laws of the State of Delaware, having its principal office at 71 Rogers Avenue, Cambridge, Massachusetts 02142 (herein called the “Company”), and U.S. BANK NATIONAL ASSOCIATION, a national banking association organized under the laws of the United States, as Trustee hereunder (herein called the “Trustee”).

EPIX MEDICAL, INC. 3% CONVERTIBLE SENIOR NOTES DUE 2024 PURCHASE AGREEMENT
Purchase Agreement • June 7th, 2004 • Epix Medical Inc • In vitro & in vivo diagnostic substances • New York

SG COWEN & CO., LLC NEEDHAM & COMPANY, INC. WELLS FARGO SECURITIES, LLC WR HAMBRECHT + CO. LLC As Representatives of the several Initial Purchasers c/o SG Cowen & Co., LLC 1221 Avenue of the Americas New York, New York 10020

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