0001104659-05-027338 Sample Contracts

VERTEX PHARMACEUTICALS INCORPORATED (a Massachusetts corporation) 11,750,000 Shares of Common Stock PURCHASE AGREEMENT
Vertex Pharmaceuticals Incorporated • June 8th, 2005 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • New York

We have acted as outside counsel for the Company (as defined in the Purchase Agreement) in connection with the preparation, execution and delivery of the Purchase Agreement and the consummation of the transactions contemplated thereby. In connection therewith, we have examined executed originals or counterparts of the Purchase Agreement, the Registration Statement, the Prospectus and such other documents as we have deemed necessary for purposes of this opinion.

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