0001104659-05-045526 Sample Contracts

3,566,000 Shares Acusphere, Inc. COMMON STOCK UNDERWRITING AGREEMENT
Underwriting Agreement • September 23rd, 2005 • Acusphere Inc • Pharmaceutical preparations • New York

The undersigned hereby acknowledges and agrees that written notice of any waiver of the extension of the Lock-Up Period, if any, pursuant to the previous paragraph will be delivered by Piper Jaffray & Co. to the Company and that any such notice properly delivered will be deemed to have been given to, and received by, the undersigned.

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