0001104659-05-051619 Sample Contracts

EXECUTION COPY September 14, 2005 Michael D. Webb EPIX Pharmaceuticals, Inc. Cambridge, MA 02142 Dear Michael:
Separation Agreement • November 2nd, 2005 • EPIX Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances • Massachusetts

The purpose of this letter agreement (hereinafter the “Agreement”) is to confirm the terms of your separation from EPIX Pharmaceuticals, Inc. (“EPIX” or “Company”). The Consideration described below is contingent on your agreement to and compliance with the terms of this Agreement. The Effective Date of this Agreement shall be the eighth day following the day that you sign it.

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EMPLOYMENT AGREEMENT
Employment Agreement • November 2nd, 2005 • EPIX Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances • Massachusetts

This EMPLOYMENT AGREEMENT, dated as of September 21, 2005 (the “Signing Date”), between EPIX Pharmaceuticals, Inc. (the “Company”), and Michael J. Astrue (the “Executive”),

Severance and Incentive Agreement
Severance Agreement • November 2nd, 2005 • EPIX Pharmaceuticals, Inc. • In vitro & in vivo diagnostic substances

This Severance and Incentive Agreement (the “Agreement”) is made and entered into as of September 14, 2005 (the “Effective Date”), by and between EPIX Pharmaceuticals, Inc. (the “Company”) and Andrew Uprichard (the “Executive”), to fully recognize the Executive’s contributions to the Company and to assure continuous harmonious conduct of the Company’s affairs.

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