0001104659-06-045625 Sample Contracts

ARENA PHARMACEUTICALS, INC. WARRANT
Arena Pharmaceuticals Inc • July 6th, 2006 • Pharmaceutical preparations • New York

Arena Pharmaceuticals, Inc., a Delaware corporation (the “Company”), hereby certifies that, for value received, Smithfield Fiduciary LLC or its registered assigns (the “Holder”), is entitled to purchase from the Company up to a total of 829,856 shares of common stock, $0.0001 par value per share (the “Common Stock”), of the Company (each such share, a “Warrant Share” and all such shares, the “Warrant Shares”) at an exercise price equal to $15.49 per share (as adjusted from time to time as provided in Section 9, the “Exercise Price”), at any time and from time to time from and after the Effective Date (as defined below) and through and including the seven (7) year anniversary of the Effective Date (the “Expiration Date”), and subject to the following terms and conditions.

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Amendment to Registration Rights Agreement
Registration Rights Agreement • July 6th, 2006 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment to Registration Rights Agreement (this “Amendment”), dated as of June 30, 2006, is entered into by and among Arena Pharmaceuticals, Inc. (the “Company”) and Smithfield Fiduciary LLC (“Purchaser”).

Amendment to Registration Rights Agreement
Registration Rights Agreement • July 6th, 2006 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment to Registration Rights Agreement (this “Amendment”), dated as of June 30, 2006, is entered into by and among Arena Pharmaceuticals, Inc. (the “Company”) and Mainfield Enterprises, Inc. (“Purchaser”).

SETTLEMENT AGREEMENT AND RELEASE
Settlement Agreement and Release • July 6th, 2006 • Arena Pharmaceuticals Inc • Pharmaceutical preparations • New York

This settlement agreement and release (“Agreement”), dated as of June 30, 2006, is entered into by and between Arena Pharmaceuticals, Inc., a Delaware corporation with its principal place of business at 6166 Nancy Ridge Drive, San Diego, California 92121 (“Arena”), and Smithfield Fiduciary LLC, a Cayman Islands limited liability company having its principal place of business at c/o Harmonic Fund Services, The Cayman Corporate Center, 4th Floor, 27 Hospital Road, George Town, Grand Cayman, Cayman Islands, British West Indies (“Smithfield”) (each, a “Party” and collectively the “Parties”):

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