0001104659-07-015515 Sample Contracts

August 17, 2006 [Name] [Title] The Medicines Company 8 Campus Drive Parsippany, NJ 07054 Dear [Name]:
Medicines Co /De • March 1st, 2007 • Pharmaceutical preparations

This letter agreement amends and restates in its entirety the letter agreement between you and The Medicines Company (the “Company”) dated December 21, 2005 regarding the subject matter hereof.

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