0001104659-07-015515 Sample Contracts

August 17, 2006 [Name] [Title] The Medicines Company 8 Campus Drive Parsippany, NJ 07054 Dear [Name]:
Letter Agreement • March 1st, 2007 • Medicines Co /De • Pharmaceutical preparations

This letter agreement amends and restates in its entirety the letter agreement between you and The Medicines Company (the “Company”) dated December 21, 2005 regarding the subject matter hereof.

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