0001104659-07-074046 Sample Contracts

Amendment to Employment Agreement
Employment Agreement • October 10th, 2007 • Arqule Inc • Pharmaceutical preparations • Massachusetts

This Amendment to Employment Agreement (“Amendment”) is entered into by and between ArQule, Inc., a Delaware corporation (the “Company”) with its principal offices at 19 Presidential Way, Woburn, Massachusetts 01801, and Stephen A. Hill, M.D. (“Executive”) whose current principal residential address is 26 Dole Hill Lane, Boxford, MA 01921. The purpose of this Amendment is to amend the Employment Agreement dated as of January 1, 2004 between the Company and Executive (the “Agreement”). This Amendment shall be effective as of [date].

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Amendment to Employment Agreement
Employment Agreement • October 10th, 2007 • Arqule Inc • Pharmaceutical preparations • Massachusetts

This Amendment to Employment Agreement (“Amendment”) is entered into by and between ArQule, Inc., a Delaware corporation (the “Company”) with its principal offices at 19 Presidential Way, Woburn, Massachusetts 01801, and Peter Lawrence (“Executive”) whose current principal residential address is 29 Fairfield Street, Unit 4-5, Boston, MA 02116. The purpose of this Amendment is to amend the Employment Agreement dated as of April 13, 2006 between the Company and Executive (the “Agreement”). This Amendment shall be effective as of October 4, 2007.

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