0001104659-08-025381 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • April 18th, 2008 • Arqule Inc • Pharmaceutical preparations

This Employment Agreement (the “Agreement”) dated as of April 15, 2008 (the “Execution Date”) is made by and between ArQule, Inc., a Delaware corporation (the “Company”) with its principal offices at 19 Presidential Way, Woburn, Massachusetts 01801, and Paolo Pucci (“Executive”) whose current principal residential address is 47 Bonnie Brook Road, Westport, Connecticut 06880.

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Second Amendment to Employment Agreement
Employment Agreement • April 18th, 2008 • Arqule Inc • Pharmaceutical preparations • Massachusetts

This Second Amendment to Employment Agreement (“Second Amendment”) is entered into by and between ArQule, Inc., a Delaware corporation (the “Company”) with its principal offices at 19 Presidential Way, Woburn, Massachusetts 01801, and Peter Lawrence (“Executive”) whose current principal residential address is 29 Fairfield Street, Unit 4-5, Boston, MA 02116. The purpose of this Second Amendment is to amend the Employment Agreement dated as of April 13, 2006 between the Company and Executive (the “Agreement”), as amended by the amendment effective as of October 4, 2007 (“First Amendment”). This Second Amendment shall be effective as of April 14, 2008.

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