0001104659-08-034482 Sample Contracts

SECOND AMENDMENT TO PATENT TRANSFER AGREEMENT
Patent Transfer Agreement • May 20th, 2008 • Acusphere Inc • Pharmaceutical preparations

THIS IS A SECOND AMENDMENT, dated as of May 15, 2008, to that certain PATENT TRANSFER AGREEMENT dated as of May 11, 2005 (the “Patent Transfer Agreement”) by and between Bayer Schering Pharma AG, a German corporation having its principal place of business in Müllerstraße 178, 13353 Berlin, Germany (hereinafter referred to as “BSP”) and Acusphere, Inc., a Delaware corporation having its place of business at 500 Arsenal Street, Watertown, MA 02472, USA (hereinafter referred to as “Acusphere”)

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SECOND AMENDMENT TO LICENSE AGREEMENT
License Agreement • May 20th, 2008 • Acusphere Inc • Pharmaceutical preparations

This Second Amendment to License Agreement (the “Amendment”) is effective and entered into as of May 15, 2008 by and between GE Healthcare AS, a Norwegian corporation (“GEHC”), and Acusphere Inc., a Delaware corporation (“ACUS”) (GEHC and ACUS collectively are the “Parties”).

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