0001104659-09-010179 Sample Contracts

THIRD AMENDMENT TO PATENT TRANSFER AGREEMENT
Patent Transfer Agreement • February 17th, 2009 • Acusphere Inc • Pharmaceutical preparations

THIS IS A THIRD AMENDMENT, dated as of February 12, 2009, to that certain PATENT TRANSFER AGREEMENT dated as of May 11, 2005 (the “Patent Transfer Agreement”) by and between Bayer Schering Pharma AG, a German corporation having its principal place of business in Müllerstraße 178, 13353 Berlin, Germany (hereinafter referred to as “BSP”) and Acusphere, Inc., a Delaware corporation having its place of business at 500 Arsenal Street, Watertown, MA 02472, USA (hereinafter referred to as “Acusphere”)

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THIRD AMENDMENT TO LICENSE AGREEMENT
License Agreement • February 17th, 2009 • Acusphere Inc • Pharmaceutical preparations

This Third Amendment to License Agreement (the “Amendment”) is effective and entered into as of February 11, 2009 by and between GE Healthcare AS, a Norwegian corporation (“GEHC”), and Acusphere Inc., a Delaware corporation (“ACUS”) (GEHC and ACUS collectively are the “Parties”).

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