0001104659-10-050532 Sample Contracts

SUBORDINATED INDENTURE VERTEX PHARMACEUTICALS INCORPORATED, ISSUER AND U.S. BANK NATIONAL ASSOCIATION, TRUSTEE INDENTURE Dated as of September 28, 2010 Subordinated Debt Securities
Vertex Pharmaceuticals Inc / Ma • September 29th, 2010 • Pharmaceutical preparations • New York

INDENTURE, dated as of September 28, 2010, between VERTEX PHARMACEUTICALS INCORPORATED, a corporation duly organized and existing under the laws of the Commonwealth of Massachusetts, having its principal office at 130 Waverly Street, Cambridge, Massachusetts 02139 (the “Company”), and U.S. BANK NATIONAL ASSOCIATION, as trustee (the “Trustee”):

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FIRST SUPPLEMENTAL INDENTURE BETWEEN VERTEX PHARMACEUTICALS INCORPORATED, AS ISSUER AND U.S. BANK NATIONAL ASSOCIATION, AS TRUSTEE DATED AS OF SEPTEMBER 28, 2010 ESTABLISHING THE SERIES OF SECURITIES DESIGNATED AS 3.35% CONVERTIBLE SENIOR SUBORDINATED...
Supplemental Indenture • September 29th, 2010 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • New York

FIRST SUPPLEMENTAL INDENTURE (the “Supplemental Indenture”), dated as of September 28, 2010, between VERTEX PHARMACEUTICALS INCORPORATED, a corporation duly organized and existing under the laws of the Commonwealth of Massachusetts, having its principal office at 130 Waverly Street, Cambridge, Massachusetts 02139, and U.S. BANK NATIONAL ASSOCIATION, as trustee, having its principal corporate trust office at One Federal Street, Boston, Massachusetts 02110, supplementing and amending the Subordinated Indenture (the “Base Indenture”) dated as of September 28, 2010 between the Company and the Trustee.

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