0001104659-22-028775 Sample Contracts

Cara Therapeutics, Inc., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [•], 20 Debt Securities
Indenture • March 1st, 2022 • Cara Therapeutics, Inc. • Pharmaceutical preparations • New York

INDENTURE, dated as of [•], 20 , among Cara Therapeutics, Inc., a Delaware corporation (the “Company”), and [TRUSTEE], as trustee (the “Trustee”):

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AS WARRANT AGENT
Preferred Stock Warrant Agreement • March 1st, 2022 • Cara Therapeutics, Inc. • Pharmaceutical preparations • New York

This Preferred Stock Warrant Agreement (this “Agreement”), dated as of [•], between Cara Therapeutics, Inc., a Delaware corporation (the “Company”), and [•], a [corporation] [national banking association] organized and existing under the laws of [•] and having a corporate trust office in [•], as warrant agent (the “Warrant Agent”).

OPEN MARKET SALE AGREEMENTSM
Open Market Sale Agreement • March 1st, 2022 • Cara Therapeutics, Inc. • Pharmaceutical preparations • New York

Cara Therapeutics, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), shares of the Company’s common stock, par value $0.001 per share (the “Common Shares”) on the terms set forth in this agreement (this “Agreement”).

AS WARRANT AGENT
Warrant Agreement • March 1st, 2022 • Cara Therapeutics, Inc. • Pharmaceutical preparations • New York

This Debt Securities Warrant Agreement (this “Agreement”), dated as of [•], between Cara Therapeutics, Inc., a Delaware corporation (the “Company”), and [•], a [corporation] [national banking association] organized and existing under the laws of [•] and having a corporate trust office in [•], as warrant agent (the “Warrant Agent”).

AS WARRANT AGENT
Warrant Agreement • March 1st, 2022 • Cara Therapeutics, Inc. • Pharmaceutical preparations • New York

This Common Stock Warrant Agreement (this “Agreement”), dated as of [•], between Cara Therapeutics, Inc., a Delaware corporation (the “Company”), and [•], a [corporation] [national banking association] organized and existing under the laws of [•] and having a corporate trust office in [•], as warrant agent (the “Warrant Agent”).

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