0001140361-18-038676 Sample Contracts

AKCEA THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT DATED AS OF
Common Stock Warrant Agreement • September 18th, 2018 • Akcea Therapeutics, Inc. • Pharmaceutical preparations • New York

This Common Stock Warrant Agreement (this “Agreement”), dated as of [•], between AKCEA THERAPEUTICS, INC., a Delaware corporation (the “Company”) and [•], a [corporation] [national banking association] organized and existing under the laws of [•] and having a corporate trust office in [•], as warrant agent (the “Warrant Agent”).

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AKCEA THERAPEUTICS, INC. FORM OF PREFERRED STOCK WARRANT AGREEMENT
Preferred Stock Warrant Agreement • September 18th, 2018 • Akcea Therapeutics, Inc. • Pharmaceutical preparations • New York

THIS PREFERRED STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [•], between AKCEA THERAPEUTICS, INC., a Delaware corporation (the “Company”) and [•], a [corporation] [national banking association] organized and existing under the laws of [•] and having a corporate trust office in [•], as warrant agent (the “Warrant Agent”).

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AKCEA THERAPEUTICS, INC. FORM OF DEBT SECURITIES WARRANT AGREEMENT
Debt Securities Warrant Agreement • September 18th, 2018 • Akcea Therapeutics, Inc. • Pharmaceutical preparations • New York

THIS DEBT SECURITIES WARRANT AGREEMENT (this “Agreement”), dated as of [•], between AKCEA THERAPEUTICS, INC., a Delaware corporation (the “Company”) and [•], a [corporation] [national banking association] organized and existing under the laws of [•] and having a corporate trust office in [•], as warrant agent (the “Warrant Agent”).

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Akcea Therapeutics, Inc.,
Indenture • September 18th, 2018 • Akcea Therapeutics, Inc. • Pharmaceutical preparations • New York

Indenture, dated as of [·], 20__, among Akcea Therapeutics, Inc., a Delaware corporation (the “Company”), and [Trustee], as trustee (the “Trustee”):

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