0001144204-06-002798 Sample Contracts

UNDERWRITING AGREEMENT Among GENTIUM, S.p.A., MAXIM GROUP LLC And I-BANKERS SECURITIES INCORPORATED Dated: June 16, 2005
Underwriting Agreement • January 26th, 2006 • Gentium S.p.A. • Pharmaceutical preparations • New York

The undersigned, Gentium, S.p.A., a Republic of Italy joint stock corporation (the “Company”), hereby confirms its agreement with Maxim Group LLC (“Maxim”) and I-Bankers Securities Incorporated (“IBS” and, together with Maxim, the “Representatives”) as Representatives of the several underwriters named on Schedule I to this Agreement (the “Underwriters”) as follows:

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PLEDGE AGREEMENT
Pledge Agreement • January 26th, 2006 • Gentium S.p.A. • Pharmaceutical preparations
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