0001144204-07-021632 Sample Contracts

CONSULTING AGREEMENT
Consulting Agreement • April 30th, 2007 • Gentium S.p.A. • Pharmaceutical preparations

This Consulting Agreement (“Agreement”) is by and between KKS-TU GmbH, a German Corporation (“KKS”), located at Otfried-Müller-Str. 45, 72076 Tubingen, Germany, and Gentium, an Italy Corporation (“Gentium”), located at Piazza XX Settembre 2, Villa Gardia (Como), Italy.

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GENTIUM S.p.A. 2007 STOCK OPTION PLAN
Award Agreement • April 30th, 2007 • Gentium S.p.A. • Pharmaceutical preparations
LOAN AGREEMENT No. 0367050568897
Loan Agreement • April 30th, 2007 • Gentium S.p.A. • Pharmaceutical preparations
COMMERCIAL LEASE AGREEMENT
Lease Agreement • April 30th, 2007 • Gentium S.p.A. • Pharmaceutical preparations

FINSIRTON SPA, resident in VILLA GUARDIA, Piazza XX Settembre, 2, Tax Code 02827580131, Lessor, LEASES THE FOLLOWING PROPERTY, FOR COMMERCIAL USE, to GENTIUM SPA, domiciled in the premises of the lease agreement, tax code 02098100130, Lessee,

GENTIUM S.P.A. AMENDMENT NO. 1 TO AMENDED AND RESTATED NONSTATUTORY STOCK OPTION PLAN AND AGREEMENT
Nonstatutory Stock Option Plan and Agreement • April 30th, 2007 • Gentium S.p.A. • Pharmaceutical preparations

THIS AMENDMENT NO. 1 to the Amended and Restated Nonstatutory Stock Option Plan and Agreement (the “Plan”) of Gentium S.p.A. (the “Company”) is made as of March 26, 2007. All capitalized terms not defined herein are set forth in the Plan.

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