0001144204-07-067088 Sample Contracts

Gentium SpA Piazza XX Settembre, 2 - 22079 Villa Guardia (CO) Italy
Gentium S.p.A. • December 12th, 2007 • Pharmaceutical preparations

Reference is made to the License and Supply Agreement dated as of December 7, 2001, as amended (the “Agreement”), between Sigma-Tau Pharmaceuticals, Inc. (“Sigma-Tau”) and Gentium S.p.A. (“Gentium”), and to Gentium’s proposal that Sigma-Tau share in certain costs relating to the Development of the Product (all capitalized terms used and not defined herein having the meanings set forth in the Agreement).

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AMENDMENT NO. 1 TO ACTIVE INGREDIENT SUPPLY AGREEMENT
Active Ingredient Supply Agreement • December 12th, 2007 • Gentium S.p.A. • Pharmaceutical preparations

This Amendment No. 1 (this “Amendment”) to the Active Ingredient Supply Agreement is entered into and effective as of December 7, 2007 by and between Sirton Pharmaceuticals S.p.A. (“Sirton”) and Gentium S.p.A. (“Gentium”).

MANUFACTURING AGREEMENT
Manufacturing Agreement • December 12th, 2007 • Gentium S.p.A. • Pharmaceutical preparations

SIRTON PHARMACEUTICALS S.p.A., an Italian company with legal headquarters in Villa Guardia (CO), ITALY, Piazza XX Settembre 2, I - 22079 (hereafter indicated as “SIRTON”), represented by Mr. Sauro Carsana, as VP. Finance;

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