0001144204-08-053912 Sample Contracts

AGREEMENT AND PLAN OF MERGER BY AND AMONG YM BIOSCIENCES INC., YM BIOSCIENCES USA INC., YM BIOSCIENCES U.S. OPERATIONS INC., EXIMIAS PHARMACEUTICAL CORPORATION AND ORBIMED ADVISORS, LLC, AS STOCKHOLDER REPRESENTATIVE April 13, 2006
Merger Agreement • September 22nd, 2008 • Ym Biosciences Inc • Pharmaceutical preparations • Delaware

THIS AGREEMENT AND PLAN OF MERGER (this “Agreement”) is entered into on April 13, 2006, by and among YM BioSciences Inc., a corporation existing under the laws of Nova Scotia, Canada (“Acquiror”), YM BioSciences USA Inc., a Delaware corporation and wholly-owned subsidiary of Acquiror, (“YM BioSciences USA”), YM BioSciences U.S. Operations Inc., a Delaware corporation and wholly-owned subsidiary of YM BioSciences USA (“Merger Sub”), Eximias Pharmaceutical Corporation, a Delaware corporation (“Target”), and OrbiMed Advisors, LLC on behalf of the Series D Stockholders (in such capacity referred to as the “Stockholder Representative”). Certain capitalized terms used in this Agreement are defined in Exhibit A hereto.

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CLINICAL RESEARCH SERVICES AGREEMENT BETWEEN YM BIOSCIENCES, INC. AND PHARM- OLAM INTERNATIONAL LTD. YB1002-203Taxotere
Clinical Research Services Agreement • September 22nd, 2008 • Ym Biosciences Inc • Pharmaceutical preparations • Ontario

This Clinical Research Services Agreement (this Agreement) is made and entered into effective as of 10 December 2004 (the “Effective Date”), by and between YM BIOSCIENCES, INC. (hereafter “YM”), a Canadian corporation, with its principal office at 5045 Orbitor Drive, Building 11, Suite 400, Mississauga, Ontario L4W 4Y4, Canada, and PHARM-OLAM INTERNATIONAL Ltd. (hereafter “POI”), a Texas limited partnership, with its principal office at 450 N Sam Houston Parkway, Suite 250, Houston, TX 77060, United States.

LEASE AMENDING AND EXTENSION AGREEMENT
Lease Amending and Extension Agreement • September 22nd, 2008 • Ym Biosciences Inc • Pharmaceutical preparations
Contract
Development and Licence Agreement • September 22nd, 2008 • Ym Biosciences Inc • Pharmaceutical preparations • London
Work Order #1 Dated November 9, 2007
Work Order • September 22nd, 2008 • Ym Biosciences Inc • Pharmaceutical preparations

The services described herein will be provided in accordance with the terms and conditions of the Master Services Agreement, dated August 24, 2007, between AAIPharma Inc., on behalf of itself and its subsidiaries (collectively, ‘AAIPharma’) and YM Biosciences USA Inc. (hereinafter referred to as “YMB USA”).

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