0001144204-09-009613 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • February 18th, 2009 • Novelos Therapeutics, Inc. • Pharmaceutical preparations • New York

This Registration Rights Agreement (the “Agreement”) is made and entered into as of this 11th day of February, 2009 by and among Novelos Therapeutics, Inc., a Delaware corporation (the “Company”), Purdue Pharma L.P., a Delaware limited partnership (“Purdue”), the “Series D Investors” named in that certain Securities Purchase Agreement, dated March 26, 2008, as amended on April 9, 2008, by and among the Company and the Series D Investors (the “Series D Securities Purchase Agreement”), and the holders of the Series B Warrants (as defined below) (the Company, Purdue, the Series D Investors and the holders of the Series B Warrants are sometimes referred to herein individually as “Party” and collectively as the “Parties”). Capitalized terms not otherwise defined herein shall have the meanings ascribed thereto in the Series E Securities Purchase Agreement.

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WARRANT AMENDMENT AGREEMENT
Warrant Amendment Agreement • February 18th, 2009 • Novelos Therapeutics, Inc. • Pharmaceutical preparations

THIS WARRANT AMENDMENT AGREEMENT (“Amendment”) is made as of this 11th day of February, 2009 by and among Novelos Therapeutics, Inc., a Delaware corporation (the “Company”) and the undersigned holders of warrants to purchase 7,500,000 shares of the Company’s common stock dated May 2, 2007 (the “Series B Warrants”) issued pursuant a certain Securities Purchase Agreement, dated as of April 12, 2007, by and among the Corporation and the Investors signatory thereto (as amended on May 2, 2007, the “Series B Purchase Agreement”). All capitalized terms used but not defined herein shall have the meanings ascribed thereto in the Series B Warrants.

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • February 18th, 2009 • Novelos Therapeutics, Inc. • Pharmaceutical preparations • New York

THIS SECURITIES PURCHASE AGREEMENT (“Agreement”) is made as of this 11th day of February, 2009 by and among Novelos Therapeutics, Inc., a Delaware corporation (the “Company”) and Purdue Pharma L.P., a Delaware limited partnership (“Purdue”).

NOVELOS THERAPEUTICS, INC. SERIES D PREFERRED STOCK CONSENT AND AGREEMENT TO EXCHANGE
Consent and Agreement to Exchange • February 18th, 2009 • Novelos Therapeutics, Inc. • Pharmaceutical preparations • New York

This CONSENT AND AGREEMENT TO EXCHANGE (the “Agreement”) dated as of February 10, 2009, is entered into by and among Novelos Therapeutics, Inc., a Delaware corporation (the “Company”) and the entities listed on the signature pages hereto (collectively, the “Series D Investors”) (the Company and Series D Investors are sometimes referred to herein individually as a “Party” and collectively as the “Parties”).

AMENDMENT NO. 2 TO REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • February 18th, 2009 • Novelos Therapeutics, Inc. • Pharmaceutical preparations • New York

This AMENDMENT TO REGISTRATION RIGHTS AGREEMENT (the “Amendment”) dated as of February 11, 2009, is entered into by and between Novelos Therapeutics, Inc., a Delaware Corporation (the “Company”) and the entities listed on the signature pages hereto (collectively, the “Series D Holders”).

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