Consent and Agreement to Exchange Sample Contracts

NOVELOS THERAPEUTICS, INC. SERIES D PREFERRED STOCK CONSENT AND AGREEMENT TO EXCHANGE
Consent and Agreement to Exchange • February 18th, 2009 • Novelos Therapeutics, Inc. • Pharmaceutical preparations • New York

This CONSENT AND AGREEMENT TO EXCHANGE (the “Agreement”) dated as of February 10, 2009, is entered into by and among Novelos Therapeutics, Inc., a Delaware corporation (the “Company”) and the entities listed on the signature pages hereto (collectively, the “Series D Investors”) (the Company and Series D Investors are sometimes referred to herein individually as a “Party” and collectively as the “Parties”).

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