0001188112-13-000623 Sample Contracts

SECOND AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • March 11th, 2013 • Arqule Inc • Pharmaceutical preparations • Massachusetts

This Second Amendment to Employment Agreement (“Second Amendment”), effective as of March 8, 2013 (the “Effective Date”) is entered into by and between ArQule, Inc., a Delaware corporation (the "Company") with its principal offices at 19 Presidential Way, Woburn, Massachusetts 01801, and Paolo Pucci ("Executive"). The purpose of this Second Amendment is to amend the Employment Agreement dated as of April 15, 2008 between the Company and Executive (the "Employment Agreement"), as previously amended by an agreement effective as of July 15, 2010 (the “First Amendment”). Capitalized terms used but not defined in this Second Amendment shall have the meanings ascribed to them in the Employment Agreement.

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THIRD AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • March 11th, 2013 • Arqule Inc • Pharmaceutical preparations • Massachusetts

This Third Amendment to Employment Agreement (“Third Amendment”), effective as of March 8, 2013, is entered into by and between ArQule, Inc., a Delaware corporation (the "Company") with its principal offices at 19 Presidential Way, Woburn, Massachusetts 01801, and Peter Lawrence ("Executive"). The purpose of this Third Amendment is to amend the Employment Agreement dated as of April 13, 2006 between the Company and Executive (the "Employment Agreement"), as previously amended by an agreement effective as of October 4, 2007 (the First Amendment”), and as further amended by an agreement effective as of April 14, 2008 (the “Second Amendment”). Capitalized terms used but not defined in this Third Amendment shall have the meanings ascribed to them in the Employment Agreement.

SECOND AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • March 11th, 2013 • Arqule Inc • Pharmaceutical preparations • Massachusetts

This Second Amendment to Employment Agreement (“Second Amendment”), effective as of March 8, 2013 (the “Effective Date”) is entered into by and between ArQule, Inc., a Delaware corporation (the "Company") with its principal offices at 19 Presidential Way, Woburn, Massachusetts 01801, and Brian Schwartz ("Executive"). The purpose of this Second Amendment is to amend the Employment Agreement dated as of June 17, 2008 between the Company and Executive (the "Employment Agreement"), as previously amended by an agreement effective as of February 23, 2012. Capitalized terms used but not defined in this Second Amendment shall have the meanings ascribed to them in the Employment Amendment.

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