0001193125-03-036322 Sample Contracts

Exhibit A April 11, 2003
Severance Agreement • August 14th, 2003 • Aclara Biosciences Inc • Measuring & controlling devices, nec • California

ACLARA BioSciences, Inc. (the “Company”) considers it essential to the best interests of its shareholders to foster the continuous employment of the Company’s key management personnel. In order to induce you to remain in its employ, the Company hereby agrees that after this letter agreement (this “Agreement”) has been fully executed, you shall receive the severance benefits set forth in this Agreement in the event of a Hostile Takeover (as defined below) or that your employment with the Company is terminated under the circumstances described below.

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AMENDMENT NO. 1 to the July 17, 2002 RESEARCH AGREEMENT
Research Agreement • August 14th, 2003 • Aclara Biosciences Inc • Measuring & controlling devices, nec

This AMENDMENT NO. 1 (the “Amendment”) to the July 17, 2002 RESEARCH AGREEMENT (the “Agreement”) is entered into as of April 17, 2003 (the “Amendment Effective Date”) by and between GENENTECH and ACLARA. Unless otherwise noted, all defined terms set forth in this Amendment shall have the same meaning as set forth in the Agreement.

RESEARCH AGREEMENT
Research Agreement • August 14th, 2003 • Aclara Biosciences Inc • Measuring & controlling devices, nec • California

THIS RESEARCH AGREEMENT (the “Agreement”), effective July 17, 2002 (“Effective Date”), between ACLARA BIOSCIENCES, INC., having a principal place of business at 1288 Pear Avenue, Mountain View, California 94043 (“ACLARA”) and GENENTECH, INC., having a principal place of business at 1 DNA Way, South San Francisco, CA 94080 (“GENENTECH”).

ACLARA BioSciences, Inc. Letterhead] [Date], 2003
Non-Employee Director Change in Control Agreement • August 14th, 2003 • Aclara Biosciences Inc • Measuring & controlling devices, nec

ACLARA BioSciences, Inc. (the “Company”) considers it essential to the best interests of its shareholders to foster the continuous service of the Company’s non-employee directors. In this regard, the Company’s Board of Directors (the “Board”) has decided to reinforce and encourage the continued attention and dedication of non-employee members of the Board, including yourself, to their duties without the distraction arising from the possibility of a change in control of the Company.

April 11, 2003 Mr. Michael J. Dunn La Jolla, California 92037 Dear Mike:
Employment Agreement • August 14th, 2003 • Aclara Biosciences Inc • Measuring & controlling devices, nec • California
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