0001193125-03-077338 Sample Contracts

Tularik Inc. 6,000,000 Shares Common Stock ($0.001 Par Value) UNDERWRITING AGREEMENT
Underwriting Agreement • November 12th, 2003 • Tularik Inc • Pharmaceutical preparations • New York

Tularik Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell to the underwriters named in Schedule I hereto (the “Underwriters”), for whom you are acting as representatives (the “Representatives”) an aggregate of 6,000,000 shares and, at the election of the Underwriters, up to an additional 900,000 shares of common stock, $0.001 par value per share (the “Common Stock”), of the Company. The aggregate of 6,000,000 shares to be sold by the Company is herein called the “Firm Shares” and the aggregate of 900,000 additional shares to be sold by the Company is herein called the “Optional Shares.” The Firm Shares and the Optional Shares that the Underwriters elect to purchase pursuant to Section 1 hereof are herein collectively called the “Shares.” The Shares are described in the Prospectus which is referred to below.

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AMENDMENT TO RIGHTS AGREEMENT BETWEEN TULARIK INC. AND WELLS FARGO BANK MINNESOTA, N.A.
Rights Agreement • November 12th, 2003 • Tularik Inc • Pharmaceutical preparations • Delaware

THIS AMENDMENT TO RIGHTS AGREEMENT (the “Amendment”) is made this 10th day of November, 2003, by and between TULARIK INC., a Delaware corporation (the “Company”), and WELLS FARGO BANK MINNESOTA, N.A. (the “Rights Agent”).

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