0001193125-04-194041 Sample Contracts

2,200,000 Shares of Common Stock Inspire Pharmaceuticals, Inc. UNDERWRITING AGREEMENT
Underwriting Agreement • November 12th, 2004 • Inspire Pharmaceuticals Inc • Pharmaceutical preparations • New York

Inspire Pharmaceuticals, Inc., a corporation organized and existing under the laws of Delaware (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell to Deutsche Bank Securities Inc. (the “Underwriter”) an aggregate of 2,200,000 shares (the “Firm Shares”) of its common stock, par value $0.001 per share (the “Common Stock”), and, for the sole purpose of covering over-allotments in connection with the sale of the Firm Shares, at the option of the Underwriter, up to an additional 330,000 shares (the “Additional Shares”) of Common Stock. The Firm Shares and any Additional Shares purchased by the Underwriter are referred to herein as the “Shares.” The Shares are more fully described in the Prospectus referred to below.

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