0001193125-05-068450 Sample Contracts

LEASE AGREEMENT
Lease Agreement • April 1st, 2005 • New River Pharmaceuticals Inc • Pharmaceutical preparations • Virginia

THIS LEASE AGREEMENT (“Agreement”), made and executed to be effective as of August 10, 2004, by and between NEW RIVER PHARMACEUTICALS INC., a Virginia corporation (“NEW RIVER”), and THIRD SECURITY, LLC, a Virginia limited liability company (“THIRD SECURITY”),

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UNITED STATES COLLABORATION AGREEMENT BY AND AMONG SHIRE LLC SHIRE PHARMACEUTICALS GROUP PLC AND NEW RIVER PHARMACEUTICALS INC. DATED AS OF MARCH 31, 2005
Collaboration Agreement • April 1st, 2005 • New River Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS UNITED STATES COLLABORATION AGREEMENT (the “Agreement”) is dated as of March 31, 2005 by and among SHIRE LLC, a Kentucky limited liability company having a principal place of business at 9200 Brookfield Court, Florence, Kentucky 41042 (“Shire”), SHIRE PHARMACEUTICALS GROUP PLC, a British public limited company having a principal place of business at Hampshire International Business Park, Chineham, Basingstoke, England RG24 8EP, solely for purposes of the provisions of Section 15.10 of this Agreement, and NEW RIVER PHARMACEUTICALS INC., a Virginia corporation having a principal place of business at 1881 Grove Avenue, Radford, Virginia 24141 (“New River”). Shire and New River are sometimes referred to herein individually as a “Party” and collectively as the “Parties”.

RENEWAL OF SUBLEASE
Sublease Agreement • April 1st, 2005 • New River Pharmaceuticals Inc • Pharmaceutical preparations

THIS RENEWAL OF SUBLEASE is made and entered into this 16th day of November, 2004, by and between Veterinary Technologies Corporation, hereinafter called Tenant; New River Pharmaceuticals, Inc., hereinafter called Subtenant; and Virginia Tech Foundation, Inc., hereinafter called Landlord. The terms Tenant and Subtenant are intended to include the successors and assigns of the original parties and their heirs, legal representatives, successors and assigns of the respective entities.

ROW TERRITORY LICENSE AGREEMENT BY AND AMONG SHIRE PHARMACEUTICALS IRELAND LIMITED SHIRE PHARMACEUTICALS GROUP PLC AND NEW RIVER PHARMACEUTICALS INC. DATED AS OF MARCH 31, 2005
Row Territory License Agreement • April 1st, 2005 • New River Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS ROW TERRITORY LICENSE AGREEMENT (the “Agreement”) is dated as of March 31, 2005 by and among SHIRE PHARMACEUTICALS IRELAND LIMITED, an Irish resident company having a principal place of business at 2nd Floor, Unit 1A, Citylink Business Park, Old Naas Road, Dublin 12, Ireland (“Shire”), SHIRE PHARMACEUTICALS GROUP PLC, a British public limited company having a principal place of business at Hampshire International Business Park, Chineham, Basingstoke, England RG24 8EP, solely for purposes of the provisions of Section 14.10 of this Agreement, and NEW RIVER PHARMACEUTICALS INC., a Virginia corporation having a principal place of business at 1881 Grove Avenue, Radford, Virginia 24141 (“New River”). Shire and New River are sometimes referred to herein individually as a “Party” and collectively as the “Parties”.

SERVICES AGREEMENT
Services Agreement • April 1st, 2005 • New River Pharmaceuticals Inc • Pharmaceutical preparations • Virginia

THIS SERVICES AGREEMENT (this “Agreement”) is made and entered into as of the 10th day of August, 2004 by and between Third Security, LLC, a Virginia limited liability company (“THIRD SECURITY”), and New River Pharmaceuticals Inc., a Virginia corporation, including all of its now or hereafter existing subsidiaries (“NEW RIVER”).

MODIFICATION OF LEASE
Lease Modification • April 1st, 2005 • New River Pharmaceuticals Inc • Pharmaceutical preparations

THIS MODIFICATION OF LEASE is made and entered into as of the 1st day of August, 2004, by and between Virginia Tech Foundation, Inc., hereinafter called the Landlord, and New River Pharmaceuticals Inc., hereinafter called Tenant. The terms Landlord and Tenant are intended to include the successors and assigns of the original parties and their heirs, legal representatives, successors and assigns of the respective entities.

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