0001193125-06-011214 Sample Contracts

Re: Amendment 3 to Development, Commercialization and Supply License Agreement
Development, Commercialization and Supply License Agreement • January 25th, 2006 • Durect Corp • Pharmaceutical preparations

Reference is made to the Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. (“Endo”) and DURECT Corporation (“DURECT”) effective November 8, 2002, as last amended November 22, 2004 (the “Agreement”). Effective on the date written above, Endo and DURECT hereby agree to amend the Agreement as follows:

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