Exhibit 10.42.3 [DURECT LETTERHEAD] November 22, 2004 BY FACSIMILE AND EXPRESS MAIL CONFIDENTIAL Peter A. Lankau President Endo Pharmaceuticals Inc. 100 Painters Drive Chadds Ford, PA 19317 Re: Amendment 2 to Development, Commercialization and Supply...Development, Commercialization and Supply License Agreement • November 29th, 2004 • Endo Pharmaceuticals Holdings Inc • Pharmaceutical preparations
BY FACSIMILE AND EXPRESS MAIL CONFIDENTIAL Peter A. Lankau President Endo Pharmaceuticals Inc. Chadds Ford, PA 19317Development, Commercialization and Supply License Agreement • November 29th, 2004 • Durect Corp • Pharmaceutical preparations
Reference is made to the Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. (“Endo”) and DURECT Corporation (“DURECT”) effective November 8, 2002, as amended effective January 28, 2004 (“Agreement”). Effective on the date written above, Endo and DURECT hereby agree to amend the Agreement as follows:
Re: Amendment to Development, Commercialization and Supply License AgreementDevelopment, Commercialization and Supply License Agreement • March 11th, 2004 • Durect Corp • Pharmaceutical preparations
Reference is made to the Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. (“Endo”) and DURECT Corporation (“DURECT”) effective November 8, 2002 (“Agreement”). Effective on the date written above, Endo and DURECT hereby agree as follows:
BY FACSIMILE AND EXPRESS MAIL CONFIDENTIAL Peter A. Lankau President and CEO Endo Pharmaceuticals Inc. Chadds Ford, PA 19317 Re: Amendment 4 to Development, Commercialization and Supply License Agreement Dear Peter:Development, Commercialization and Supply License Agreement • May 10th, 2007 • Endo Pharmaceuticals Holdings Inc • Pharmaceutical preparations
Reference is made to the Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. (“Endo”) and DURECT Corporation (“DURECT”) effective November 8, 2002, as last amended January 20, 2006 (“Agreement”). Effective on the date written above, Endo and DURECT hereby agree to amend the Agreement as follows:
ContractDevelopment, Commercialization and Supply License Agreement • January 25th, 2006 • Endo Pharmaceuticals Holdings Inc • Pharmaceutical preparations
Except as set forth above, all other terms of the Agreement shall remain the same. Please sign below to indicate Endo’s agreement to the foregoing.
Re: Amendment 3 to Development, Commercialization and Supply License AgreementDevelopment, Commercialization and Supply License Agreement • January 25th, 2006 • Durect Corp • Pharmaceutical preparations
Reference is made to the Development, Commercialization and Supply License Agreement between Endo Pharmaceuticals Inc. (“Endo”) and DURECT Corporation (“DURECT”) effective November 8, 2002, as last amended November 22, 2004 (the “Agreement”). Effective on the date written above, Endo and DURECT hereby agree to amend the Agreement as follows:
