0001193125-09-038442 Sample Contracts

Re: First Amendment to the Letter Agreement
Adolor Corp • February 26th, 2009 • Pharmaceutical preparations

This letter (this “First Amendment”) will amend that certain letter agreement dated February 28, 2008, between Adolor Corporation (the “Company”) and you (the “Letter Agreement”), a copy of the Letter Agreement is appended to this letter as Exhibit A.

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Re: Third Amendment to the Letter Agreement
Letter Agreement • February 26th, 2009 • Adolor Corp • Pharmaceutical preparations

This letter (this “Third Amendment”) will amend that certain letter agreement dated October 24, 2002, between you and Adolor Corporation (the “Company”) (the “Letter Agreement”), as amended January 26, 2004 (“First Amendment”) and December 14, 2006 (“Second Amendment”), a copy of the Letter Agreement, the First Amendment and Second Amendment (together, the “Agreement”) are appended to this letter as Exhibit A.

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