0001193125-09-205676 Sample Contracts

October 7, 2009 Invus Public Equities, L.P. c/o The Invus Group, LLC
Invus, L.P. • October 8th, 2009 • Pharmaceutical preparations • New York
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AMENDMENT TO SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • October 8th, 2009 • Invus, L.P. • Pharmaceutical preparations • New York

This Amendment to Securities Purchase Agreement (this “Amendment”) is entered into as of October 7, 2009 by and between Invus, L.P., a Bermuda limited partnership (the “Investor”), and Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Securities Purchase Agreement (as defined below).

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