0001193125-11-038479 Sample Contracts

February 16, 2011 VIA HAND DELIVERY Graham Cooper c/o Orexigen Therapeutics, Inc. La Jolla, CA 92037 Dear Graham:

Severance Agreement • February 17th, 2011 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations • California

• Contract Type
  Severance Agreement
• Filed
  February 17th, 2011
• Company
  Orexigen Therapeutics, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  California

This letter agreement (the “Agreement”) summarizes the terms of your separation from employment with Orexigen Therapeutics, Inc. (the “Company”) and sets forth the severance benefits offered to help you in this transition.