0001193125-11-134338 Sample Contracts

AMENDMENT NO. 1 TO THE ASSET PURCHASE AGREEMENT
The Asset Purchase Agreement • May 10th, 2011 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 1 (the “Amendment”), effective as of January 1, 2011, is by and between Arena Pharmaceuticals GmbH (“Buyer”) and Siegfried Ltd. (“Seller”), and modifies the Asset Purchase Agreement dated December 18, 2007, by and between the Parties (the “Agreement”). All capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Agreement.

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AMENDMENT NO. 3 TO THE TOLL MANUFACTURING AGREEMENT
The Toll Manufacturing Agreement • May 10th, 2011 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 3 (the “Amendment”), effective as of January 1, 2011, is by and between Arena Pharmaceuticals GmbH (“ARENA”) and Siegfried Ltd. (“SIEGFRIED”), and modifies the Toll Manufacturing Agreement, dated January 7, 2008, as amended, by and between ARENA and SIEGFRIED (the “Agreement”). All capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Agreement.

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