The Toll Manufacturing Agreement Sample Contracts

AMENDMENT NO. 5 TO THE TOLL MANUFACTURING AGREEMENT
The Toll Manufacturing Agreement • March 15th, 2012 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 5 (the “Amendment”), effective as of November 23, 2011, is by and between Arena Pharmaceuticals GmbH (“ARENA”) and Siegfried Ltd. (“SIEGFRIED”), and modifies the Toll Manufacturing Agreement, dated January 7, 2008, as amended, by and between ARENA and SIEGFRIED (the “Agreement”). All capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Agreement.

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AMENDMENT NO. 6 TO THE TOLL MANUFACTURING AGREEMENT
The Toll Manufacturing Agreement • March 1st, 2013 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 6 (the “Amendment”), effective as of August 20, 2012, is by and between Arena Pharmaceuticals GmbH (“ARENA”) and Siegfried Ltd. (“SIEGFRIED”), and modifies the Toll Manufacturing Agreement, dated January 7, 2008, as amended, by and between ARENA and SIEGFRIED (the “Agreement”). All capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Agreement.

AMENDMENT NO. 4 TO THE TOLL MANUFACTURING AGREEMENT
The Toll Manufacturing Agreement • August 9th, 2011 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 4 (the “Amendment”), effective as of January 1, 2011, is by and between Arena Pharmaceuticals GmbH (“ARENA”) and Siegfried Ltd. (“SIEGFRIED”), and modifies the Toll Manufacturing Agreement, dated January 7, 2008, as amended, by and between ARENA and SIEGFRIED (the “Agreement”). All capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Agreement.

AMENDMENT NO. 1 TO THE TOLL MANUFACTURING AGREEMENT
The Toll Manufacturing Agreement • March 16th, 2009 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 1 (the “Amendment”), effective December 18, 2008, is by and between Arena Pharmaceuticals GmbH (“Arena”) and Siegfried Ltd. (“Siegfried”), and modifies the Toll Manufacturing Agreement, dated January 7, 2008, by and between Arena and Siegfried (the “Agreement”). All capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Agreement.

AMENDMENT NO. 3 TO THE TOLL MANUFACTURING AGREEMENT
The Toll Manufacturing Agreement • May 10th, 2011 • Arena Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 3 (the “Amendment”), effective as of January 1, 2011, is by and between Arena Pharmaceuticals GmbH (“ARENA”) and Siegfried Ltd. (“SIEGFRIED”), and modifies the Toll Manufacturing Agreement, dated January 7, 2008, as amended, by and between ARENA and SIEGFRIED (the “Agreement”). All capitalized terms used herein and not otherwise defined shall have the meanings set forth in the Agreement.

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