4,938,272 Shares of Common Stock, par value $0.001 Warrants to Purchase 2,469,136 Shares of Common Stock and 740,740 Over-Allotment Shares Over- Allotment Warrants to Purchase 370,370 Shares of Common Stock APRICUS BIOSCIENCES, INC. UNDERWRITING AGREEMENTUnderwriting Agreement • February 13th, 2012 • Apricus Biosciences, Inc. • Pharmaceutical preparations • New York
