0001193125-12-109810 Sample Contracts

AMENDMENT TO COLLABORATION, LICENSE AND SUPPLY AGREEMENT
Collaboration, License and Supply Agreement • March 12th, 2012 • Alexza Pharmaceuticals Inc. • Pharmaceutical preparations • New York

This AMENDMENT TO THE COLLABORATION, LICENSE AND SUPPLY AGREEMENT (the “Amendment”) is effective as of March 5, 2012 (the “Amendment Effective Date”) by and between ALEXZA PHARMACEUTICALS, INC., a company organized under the laws of the State of Delaware, United States (“Alexza”). and having a principal place of business at 2091 Stierlin Court, Mountain View, CA 94043, United States, and GRUPO FERRER INTERNACIONAL, S.A., a company organized under the laws of Spain (“Ferrer”), having its registered office at Av. Diagonal 549, E-08029 Barcelona, Spain.

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PARTIAL LEASE TERMINATION AGREEMENT
Partial Lease Termination Agreement • March 12th, 2012 • Alexza Pharmaceuticals Inc. • Pharmaceutical preparations • California

This Partial Lease Termination Agreement (this “Agreement”) is entered into as of February 7, 2012, by and between BRITANNIA HACIENDA VIII LLC, a Delaware limited liability company (“Landlord”), and ALEXZA PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”).

COLLABORATION, LICENSE AND SUPPLY AGREEMENT
Collaboration, License and Supply Agreement • March 12th, 2012 • Alexza Pharmaceuticals Inc. • Pharmaceutical preparations

This COLLABORATION, LICENSE AND SUPPLY AGREEMENT (“Agreement”) is entered into as of October 5th, 2011 (the “Effective Date”) between ALEXZA PHARMACEUTICALS, INC., a company organized under the laws of the State of Delaware, United States (“Alexza”), and having a principal place of business at 2091 Stierlin Court, Mountain View, CA 94043, United States, and GRUPO FERRER INTERNACIONAL, S.A., a company organized under the laws of Spain (“Ferrer”), having its registered office at Av. Diagonal 549, E-08029 Barcelona, Spain.

AMENDMENT NO.2 TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 12th, 2012 • Alexza Pharmaceuticals Inc. • Pharmaceutical preparations • California

THIS AMENDMENT NO.2 TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is entered into this 25th day of January, 2012 by and between ALEXZA PHARMACEUTICALS, INC., a Delaware corporation (“Parent”), SYMPHONY ALLEGRO, INC., a Delaware corporation (“Allegro”, and together with Parent, collectively, “Borrower”), and HERCULES TECHNOLOGY GROWTH CAPITAL, INC., a Maryland corporation (“Lender”). Capitalized terms used herein without definition shall have the same meanings given them in the Loan Agreement (as defined below).

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