0001193125-13-160271 Sample Contracts

LEASE by and between BMR-325 VASSAR STREET LLC, a Delaware limited liability company and EPIZYME, INC., a Delaware corporation
Lease • April 18th, 2013 • Epizyme, Inc. • Pharmaceutical preparations • Massachusetts

IN WITNESS WHEREOF, Tenant has executed this Acknowledgment of Phase [ ] Commencement Date and Term Expiration Date as of the date first written above.

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Epizyme, Inc. Incentive Stock Option Agreement Granted Under 2008 Stock Incentive Plan
Incentive Stock Option Agreement • April 18th, 2013 • Epizyme, Inc. • Pharmaceutical preparations
EpiZyme, Inc. Restricted Stock Agreement Granted Under 2008 Stock Incentive Plan
Restricted Stock Agreement • April 18th, 2013 • Epizyme, Inc. • Pharmaceutical preparations • Delaware
DEVELOPMENT AND COMMERCIALIZATION AGREEMENT
Development and Commercialization Agreement • April 18th, 2013 • Epizyme, Inc. • Pharmaceutical preparations • New York

THIS DEVELOPMENT AND COMMERCIALIZATION AGREEMENT (this “Agreement”) is effective as of February 28, 2013 (“Effective Date”), by and between Abbott Molecular Inc., a corporation organized under the laws of Delaware (“Abbott”), and Epizyme, Inc. (“Epizyme”), a corporation organized under the laws of Delaware.

COLLABORATION AND LICENSE AGREEMENT by and between EISAI CO., LTD. and EPIZYME, INC.
Collaboration and License Agreement • April 18th, 2013 • Epizyme, Inc. • Pharmaceutical preparations • New York

This COLLABORATION AND LICENSE AGREEMENT (this “Agreement”) is entered into and made effective as of the 1st day of April, 2011 (the “Effective Date”) by and between Epizyme, Inc., a Delaware corporation having its principal place of business at 840 Memorial Drive, Cambridge, Massachusetts 02139, U.S.A. (“EPIZYME”), and Eisai Co., Ltd., a Japan corporation, having its principal place of business at Koishikawa 4-6-10, Bunkyo-Ku, Tokyo 112-8088, Japan (“EISAI”). EPIZYME and EISAI are each referred to herein by name or as a “Party” or, collectively, as the “Parties.”

COLLABORATION AND LICENSE AGREEMENT by and between GLAXO GROUP LIMITED and EPIZYME, INC.
Collaboration and License Agreement • April 18th, 2013 • Epizyme, Inc. • Pharmaceutical preparations • New York

This COLLABORATION AND LICENSE AGREEMENT (the “Agreement”) is entered into and made effective as of the 8th day of January, 2011 (the “Effective Date”) by and between Epizyme, Inc., a Delaware corporation having its principal place of business at 840 Memorial Drive, Cambridge, Massachusetts 02139, U.S.A. (“EPIZYME”), and Glaxo Group Limited, a company existing under the laws of England, having its registered office at Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex, UB6 0NN, England (“GSK”). EPIZYME and GSK are each referred to herein by name or as a “Party” or, collectively, as the “Parties.”

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