0001193125-15-188183 Sample Contracts

Translation] TERMINATION AGREEMENT
Termination Agreement • May 14th, 2015 • Kubota Ryo • Pharmaceutical preparations

This Termination Agreement (this “Termination Agreement”) is entered into as of May 13, 2015 (the “Date”), by and between Yoichi Tsuchiya (“Tsuchiya”) and Ryo Kubota (“Kubota,” and Tsuchiya and Kubota collectively, the “Parties”).

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Translation] TERMINATION AGREEMENT
Termination Agreement • May 14th, 2015 • Kubota Ryo • Pharmaceutical preparations

This Termination Agreement (this “Termination Agreement”) is entered into as of May 13, 2015 (the “Date”), by and between Yoshitaka Kitao (“Kitao”) and Ryo Kubota (“Kubota,” and Kitao and Kubota collectively, the “Parties”).

MUTUAL TERMINATION AGREEMENT
Mutual Termination Agreement • May 14th, 2015 • Kubota Ryo • Pharmaceutical preparations • Washington

This MUTUAL TERMINATION AGREEMENT (the “Termination Agreement”) is entered into as of May 13, 2015 (the “Effective Date”), by and among Ryo Kubota, an individual (“Kubota”), and each of the undersigned shareholders (“Shareholders”) of Acucela Inc., a Washington corporation (the “Company”).

Translation] TERMINATION AGREEMENT
Termination Agreement • May 14th, 2015 • Kubota Ryo • Pharmaceutical preparations

This Termination Agreement (this “Termination Agreement”) is entered into as of May 13, 2015 (the “Date”), by and between Hikaru Shimura (“Shimura”) and Ryo Kubota (“Kubota,” and Shimura and Kubota collectively, the “Parties”).

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