0001193125-17-108513 Sample Contracts

VIA HAND DELIVERY April 3, 2017 Justin Renz [Address] [Address] Dear Justin:
Karyopharm Therapeutics Inc. • April 3rd, 2017 • Pharmaceutical preparations • Massachusetts

As we discussed, your employment with Karyopharm Therapeutics Inc. (the “Company”) will end effective April 3, 2017 (the “Resignation Date”). As we also discussed, you will be eligible to receive the severance benefits described in paragraph 1 below if you (i) sign and return this Agreement to me by April 3, 2017 (but no earlier than the Resignation Date) and comply with all terms hereof, and (ii) sign and return the Additional Release attached hereto as Attachment A no later than April 22, 2017, and do not revoke your agreement to the Additional Release (attached hereto as Attachment A). By signing and returning this Agreement and the Additional Release (and not revoking the Additional Release), you will be entering into binding agreements with the Company and will be agreeing to the terms and conditions set forth in the numbered paragraphs below, including the releases of claims set forth in paragraph 2 and the Additional Release. Therefore, you are advised to consult with an attorne

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CONSULTING AGREEMENT
Consulting Agreement • April 3rd, 2017 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations • Massachusetts

This Consulting Agreement (the “Agreement”), effective as of April 3, 2017 (the “Effective Date”), is entered into between Karyopharm Therapeutics Inc., having offices at 85 Wells Avenue, Newton, MA 02459 (the “Company”) and Justin Renz, having an address located at [address] (the “Consultant”). The Consultant and Company are referred to in this Agreement individually as a “Party” and collectively as the “Parties”.

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