0001193125-22-087458 Sample Contracts

VIA ELECTRONIC MAIL March 24, 2022 Michael Kauffman, M.D., Ph.D. Dear Michael:
Severance Agreement • March 29th, 2022 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations • Massachusetts

This letter agreement confirms our agreement with respect to your planned separation from employment with Karyopharm Therapeutics Inc. (the “Company”). As we have discussed, the Company will continue to employ you through a Transition Period (as defined below), pursuant to the terms and conditions set forth in this letter agreement.

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VIA ELECTRONIC MAIL March 24, 2022 Sharon Shacham, Ph.D., M.B.A. Dear Sharon:
Separation Agreement • March 29th, 2022 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations • Massachusetts

This letter agreement confirms our agreement with respect to your planned separation from employment with Karyopharm Therapeutics Inc. (the “Company”). As we have discussed, the Company will continue to employ you through a Transition Period (as defined below), pursuant to the terms and conditions set forth in this letter agreement.

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