0001193125-24-023071 Sample Contracts

INDEMNIFICATION AGREEMENT
Indemnification Agreement • February 5th, 2024 • Spyre Therapeutics, Inc. • Pharmaceutical preparations

This Indemnification Agreement (this “Agreement”) is entered into as of __________ by and between Spyre Therapeutics, Inc., a Delaware corporation (the “Company”), and __________ (the “Indemnitee”) and shall be deemed effective upon the earliest date that the Indemnitee is duly elected or appointed as a director or officer of the Company.

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November 22, 2023 Cameron Turtle Re: Amended and Restated Employment Letter Agreement Dear Cameron:
Letter Agreement • February 5th, 2024 • Spyre Therapeutics, Inc. • Pharmaceutical preparations

On behalf of Aeglea BioTherapeutics, Inc. (the “Company”), I am very pleased to offer you a position as Chief Executive Officer of the Company (the “Role”) pursuant to this letter agreement (the “Agreement”), provided you accept such offer as indicated by your signature below, to be effective November 22, 2023 (the “Effective Date”). This Agreement amends and restates that certain letter agreement date June 22, 2023.

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