0001285819-15-000010 Sample Contracts

First Amendment to Pharmaceutical Manufacturing and Supply Agreement
And Supply Agreement • November 9th, 2015 • Omeros Corp • Pharmaceutical preparations

This is an Amendment (this “Amendment”) to the Pharmaceutical Manufacturing and Supply Agreement dated March 5, 2014 between DSM Pharmaceuticals, Inc. (“DSM”) and Omeros Corporation (“Omeros”) (the “Master Agreement”), and is entered into as of July 7, 2015 (the “Amendment Effective Date”). All initially capitalized terms in this Amendment shall have the same meaning as set forth in the Master Agreement unless otherwise defined herein.

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FOURTH AMENDMENT TO LEASE
Lease • November 9th, 2015 • Omeros Corp • Pharmaceutical preparations

THIS FOURTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this 8 day of September, 2015 (the “Fourth Amendment Execution Date”), by and between BMR-201 ELLIOTT AVENUE LLC, a Delaware limited liability company (“Landlord”), and OMEROS CORPORATION, a Washington corporation (“Tenant”).

FIRST AMENDMENT TO COMMERCIAL SUPPLY AGREEMENT
Commercial Supply Agreement • November 9th, 2015 • Omeros Corp • Pharmaceutical preparations

This First Amendment (“Amendment”) to the Commercial Supply Agreement is made effective as of this 1st day of August, 2015 (“Amendment Effective Date”), by and between Omeros Corporation (“Omeros”) and Hospira Worldwide, Inc. (“Hospira”). Each of Hospira and Omeros is referred to herein individually as a “Party” and together as the “Parties.”

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