0001558370-17-001160 Sample Contracts

COLLABORATION, DEVELOPMENT AND LICENSE AGREEMENT
Collaboration, Development and License Agreement • February 28th, 2017 • TESARO, Inc. • Pharmaceutical preparations • New York

THIS COLLABORATION, DEVELOPMENT AND LICENSE AGREEMENT (the “Agreement”) is made and entered into as of September 28, 2016 (the “Effective Date”), by and between TESARO, Inc., a Delaware corporation with a place of business at 1000 Winter Street, Suite 3300, Waltham, Massachusetts, United States of America, 02451 (“TESARO Inc.”), TESARO Development Ltd., a Bermuda corporation with a place of business at Clarendon House, 2 Church Street, Hamilton HM 11 Bermuda (“TSRO Ltd.”, and together with “TESARO Inc.”, “TESARO”) and Zai Lab (Shanghai) Co., Ltd. having its principal office at 1043 Halei Road, Building 8, Suite 502, Pudong, Shanghai, P.R. China, 201203 (“ZAI”). TESARO and ZAI are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

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FIRST AMENDMENT TO LEASE
Bill of Sale and Agreement • February 28th, 2017 • TESARO, Inc. • Pharmaceutical preparations • Massachusetts

FIRST AMENDMENT TO LEASE dated as of January 6, 2014 (“First Amendment”), by, between and among between BP Bay Colony LLC, a Delaware limited liability company (“Landlord”) and TESARO, Inc., a Delaware corporation (“Tenant”).

FOURTH AMENDMENT TO LEASE
TESARO, Inc. • February 28th, 2017 • Pharmaceutical preparations

FOURTH AMENDMENT TO LEASE (this “Fourth Amendment”) dated as of this 6th day of October, 2016 (the “Fourth Amendment Effective Date”) by and between BP BAY COLONY LLC, a Delaware limited liability company (“Landlord”), and TESARO, INC., a Delaware corporation (“Tenant”).

SECOND AMENDMENT TO LEASE
TESARO, Inc. • February 28th, 2017 • Pharmaceutical preparations

SECOND AMENDMENT TO LEASE (this “Second Amendment”) dated as of this 23RD day of April , 2015 (the “Effective Date”) by and between BP BAY COLONY LLC, a Delaware limited liability company (“Landlord”), and TESARO, INC., a Delaware corporation (“Tenant”).

THIRD AMENDMENT TO LEASE
Lease • February 28th, 2017 • TESARO, Inc. • Pharmaceutical preparations

THIRD AMENDMENT TO LEASE (this “Third Amendment”) dated as of this 2nd day of August, 2016 (the “Third Amendment Effective Date”) by and between BP BAY COLONY LLC, a Delaware limited liability company (“Landlord”), and TESARO, INC., a Delaware corporation (“Tenant”).

BAY COLONY CORPORATE CENTER 1000 WINTER STREET WALTHAM, MASSACHUSETTS Lease Dated October 15, 2012
Agreement • February 28th, 2017 • TESARO, Inc. • Pharmaceutical preparations • Massachusetts

THIS INSTRUMENT IS AN INDENTURE OF LEASE in which the Landlord and the Tenant are the parties hereinafter named, and which relates to space in a certain building (the “Building”) known as, and with an address at, 1000 Winter Street, Waltham, Massachusetts 02451.

TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • February 28th, 2017 • TESARO, Inc. • Pharmaceutical preparations

This Amendment No. 1 (this “Amendment”), to the Collaboration and License Agreement (the “Agreement”) dated April 5, 2016, by and between Janssen Biotech, Inc., a Pennsylvania corporation (“Company”), and TESARO, Inc., a Delaware corporation (“TESARO”), is entered into as of October 10, 2016 (the “Amendment Effective Date”). Company and TESARO are sometimes referred to herein individually as a “Party” and together as the “Parties.” Capitalized terms used in this Amendment without definition have the meanings given those terms in the Agreement.

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