0001558370-24-004190 Sample Contracts

Guarantee Contract
Capital Reduction Agreement • March 28th, 2024 • CASI Pharmaceuticals, Inc. • Pharmaceutical preparations • Macau

This Guarantee Contract (this “Contract”) is entered into this 14th day of December 2023 in Huishan District, Wuxi City, Jiangsu Province, China, by and among the following parties:

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Contract
Exclusive Distribution Agreement • March 28th, 2024 • CASI Pharmaceuticals, Inc. • Pharmaceutical preparations

Information in this exhibit identified by brackets and *** has been redacted because it is not material and is the type that the Company treats as private or confidential

Capital Reduction Agreement CASI Pharmaceuticals (Wuxi) Co., Ltd. Wuxi, China December 14, 2023
Capital Reduction Agreement • March 28th, 2024 • CASI Pharmaceuticals, Inc. • Pharmaceutical preparations

This Capital Reduction Agreement of CASI Pharmaceuticals (Wuxi) Co., Ltd. (this “Agreement”) is entered into this 14th day of December 2023 (“Signing Date”) in Huishan District, Wuxi City, Jiangsu Province, China, by and among the following parties:

AMENDMENT NO. 1 TO Assignment AGREEMENT IN RESPECT OF THE TERRITORY OF CHINA
CASI Pharmaceuticals, Inc. • March 28th, 2024 • Pharmaceutical preparations

This Amendment No. 1 (“Amendment 1”) is hereby entered into as of July 31, 2023 (“Amendment 1 Effective Date”) by and between Acrotech Biopharma Inc. (“Acrotech”), having a principal place of business at 279 Princeton Hightstown Road, Suite 103, East Windsor, New Jersey 08520, and CASI Pharmaceuticals, Inc. (“CASI”), having a principal place of business at 1701-1702, China Central Office, Tower 1, No. 81 Jianguo Road, Chaoyang District, Beijing 100025 People’s Republic of China (collectively, the “Parties”).

1Information in this exhibit identified by brackets and *** has been redacted because it is not material and is the type that the Company treats as private or confidential
Assignment Agreement • March 28th, 2024 • CASI Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware
Guarantee Contract
CASI Pharmaceuticals, Inc. • March 28th, 2024 • Pharmaceutical preparations • Macau

This Guarantee Contract (this “Contract”) is entered into this 14th day of December 2023 in Huishan District, Wuxi City, Jiangsu Province, China, by and among the following parties:

Guarantee Contract
CASI Pharmaceuticals, Inc. • March 28th, 2024 • Pharmaceutical preparations • Macau

This Guarantee Contract (this “Contract”) is entered into this 14th day of December 2023 in Huishan District, Wuxi City, Jiangsu Province, China, by and among the following parties:

FOLOTYN SUPPLY AGREEMENT
Folotyn Supply Agreement • March 28th, 2024 • CASI Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This FOLOTYN SUPPLY AGREEMENT (this “Agreement”), dated as of July 31, 2023 (the “Effective Date”), is made between Acrotech Biopharma Inc., a State of Delaware corporation (“Acrotech” or “Supplier”), with offices at 279 Princeton-Hightstown Road, Suite 103, East Windsor, NJ 08520, and CASI Pharmaceuticals, Inc., a Cayman corporation (“CASI” or “Buyer”), with offices at 1701-1702, China Central Office, Tower 1, No. 81 Jianguo Road, Chaoyang District, Beijing 100025 People’s Republic of China. Supplier and Buyer are referred to as the “Parties.”

SUPPLEMENTARY AGREEMENT TO THE EXCLUSIVE DISTRIBUTION AGREEMENT
Supplementary Agreement • March 28th, 2024 • CASI Pharmaceuticals, Inc. • Pharmaceutical preparations

This Supplementary Agreement to the Exclusive Distribution Agreement (this “Supplementary Agreement”), is entered into as of 【28】February, 2024(“Effective Date”), by and between:

EXECUTION VERSION
Agreement • March 28th, 2024 • CASI Pharmaceuticals, Inc. • Pharmaceutical preparations

Information in this exhibit identified by brackets and *** has been redacted because it is not material and is the type that the Company treats as private or confidential

Contract
Assignment Agreement • March 28th, 2024 • CASI Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

Information in this exhibit identified by brackets and *** has been redacted because it is not material and is the type that the Company treats as private or confidential

Convertible Loan Agreement in respect of CASI Pharmaceuticals (Wuxi) Co., Ltd. by and among Wuxi Huicheng Yuanda Investment Partnership (Limited Partnership) on the one hand - and - CASI Pharmaceuticals (Wuxi) Co., Ltd. CASI Pharmaceuticals, Inc. CASI...
Convertible Loan Agreement • March 28th, 2024 • CASI Pharmaceuticals, Inc. • Pharmaceutical preparations

This Convertible Loan Agreement in respect of CASI Pharmaceuticals (Wuxi) Co., Ltd. (this “Agreement” or “Convertible Loan Agreement”) is entered into this 14th day of December 2023 (“Signing Date”) in Huishan District, Wuxi City, Jiangsu Province, China, by and among the following parties:

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