0001564590-17-003144 Sample Contracts

Controlled Equity OfferingSM Sales Agreement
Paratek Pharmaceuticals, Inc. • March 2nd, 2017 • Pharmaceutical preparations • New York

Paratek Pharmaceuticals, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Cantor Fitzgerald & Co. (the “Agent”), as follows:

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MANUFACTURING AND SERVICES AGREEMENT
Manufacturing and Services Agreement • March 2nd, 2017 • Paratek Pharmaceuticals, Inc. • Pharmaceutical preparations

THIS MANUFACTURING AND SERVICES AGREEMENT (this “Agreement”) is made and entered into as of November 2, 2016 (the “Effective Date”), by and between Paratek Pharmaceuticals, Inc., a corporation organized and existing under the laws of Delaware, with an address at 75 Park Plaza, 4th Floor, Boston, Massachusetts 02116, United States (“Paratek”) and CIPAN ̵̶ Companhia Industrial Produtora de Antibióticos, S.A., a corporation organized and existing under the laws of Portugal with an address at Rua da Estação, no42, 2600-726 Castanheira do Ribatejo, Portugal (“CIPAN” and, collectively with Paratek, the “Parties”, and each, a “Party”).

LEASE
Lease • March 2nd, 2017 • Paratek Pharmaceuticals, Inc. • Pharmaceutical preparations
MANUFACTURING AND SERVICES AGREEMENT
Manufacturing and Services Agreement • March 2nd, 2017 • Paratek Pharmaceuticals, Inc. • Pharmaceutical preparations

THIS MANUFACTURING AND SERVICES AGREEMENT (this “Agreement”) is made and entered into as of December 30, 2016 (the “Effective Date”), by and between Paratek Pharmaceuticals, Inc., a corporation organized and existing under the laws of Delaware, with an address at 75 Park Plaza, 4th Floor, Boston, Massachusetts 02116, United States (“Paratek”), on the one hand, and Almac Pharma Services Limited, a company organized and existing under the laws of Northern Ireland with an address at Almac House, 20 Seagoe Industrial Estate, Craigavon, Northern Ireland, BT63 5QD (“Almac”), on the other hand. Paratek and Almac are collectively referred to herein as the “Parties”, and each, a “Party”.

OFFICE LEASE THE HERITAGE ON THE GARDEN BOSTON, MASSACHUSETTS
Paratek Pharmaceuticals, Inc. • March 2nd, 2017 • Pharmaceutical preparations • Massachusetts

THIS INSTRUMENT IS AN INDENTURE OF LEASE in which the Landlord and the Tenant are the parties hereinafter named, and which relates to space in the building (the “Building”) now known as The Heritage on The Garden, the office portion of which is now numbered 75 Park Plaza, and located at the southeasterly intersection of Arlington Street and Boylston Street in Boston, Massachusetts.

AMENDMENT NO. 1 TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 2nd, 2017 • Paratek Pharmaceuticals, Inc. • Pharmaceutical preparations

This Amendment No. 1 to Loan and Security Agreement (this “Amendment”) is dated as of November 10, 2015 (the “First Amendment Date”) and is entered into by and among (a) (i) PARATEK PHARMACEUTICALS, INC. (“Inc.”), a Delaware corporation, (ii) PARATEK PHARMA, LLC, a Delaware limited liability company (“LLC” and, together with Inc., hereinafter collectively referred to as the “Borrower”) and (iii) each of its subsidiaries (hereinafter collectively referred to as the “Borrower”), (b) (i) HERCULES TECHNOLOGY II, L.P., a Delaware limited partnership, (ii) HERCULES TECHNOLOGY III, L.P., a Delaware limited partnership, and (iii) the several banks and other financial institutions or entities from time to time parties to this Agreement (collectively, referred to as “Lender”) and (c) HERCULES TECHNOLOGY GROWTH CAPITAL, INC., a Maryland corporation, in its capacity as administrative agent for itself and the Lender (in such capacity, the “Agent”). Capitalized terms used herein without definition s

Outsourcing Agreement Between Paratek Pharmaceuticals, Inc. and CARBOGEN AMCIS AG Date
This Agreement • March 2nd, 2017 • Paratek Pharmaceuticals, Inc. • Pharmaceutical preparations

CARBOGEN AMCIS AG, a company having a place of business at Hauptstrasse 171, CH 4416 Bubendorf, Switzerland (“Supplier” and, collectively with Customer, the “Parties”, and each, a “Party).

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