EXHIBIT 10.8 AMENDMENT NO. 1 TO AMENDED AND RESTATED BINDING AGREEMENT IN PRINCIPLE THIS AMENDMENT NO. 1 TO AMENDED AND RESTATED BINDING AGREEMENT IN PRINCIPLE (this "AMENDMENT") is entered into by and between PRAECIS PHARMACEUTICALS INCORPORATED, a...Amended and Restated Binding Agreement in Principle • November 13th, 2000 • Praecis Pharmaceuticals Inc • Pharmaceutical preparations • California
