Exhibit 4.3 AMENDMENT NO. 2 TO AGREEMENT IN PRINCIPLE THIS AMENDMENT NO. 2 TO AGREEMENT IN PRINCIPLE, dated as of January 27, 1998 (this "Amendment"), by and between NAPRO BIOTHERAPEUTICS, INC., a Delaware corporation (the "Company"), and the...Amendment No. 2 to Agreement in Principle • January 30th, 1998 • Napro Biotherapeutics Inc • Medicinal chemicals & botanical products • New York
