Bromfenac License Agreement Sample Contracts

SECOND AMENDMENT TO BROMFENAC LICENSE AGREEMENT
Bromfenac License Agreement • June 2nd, 2006 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances

This Second Amendment (the “Second Amendment”) is made this 31st day of May, 2006, by and between ISTA Pharmaceuticals, Inc., a Delaware corporation (“ISTA”), and Senju Pharmaceutical Co., Ltd., a legal entity organized and existing under the laws of Japan (“SENJU”).

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Yukoh Yoshida President Senju Pharmaceutical Co., Ltd. 5-8, Hiranomachi 2-chome Chuo-ku, Osaka, 541-0046 Japan Dear Mr. Yoshida:
Bromfenac License Agreement • December 17th, 2009 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances

In connection with our recent letter regarding changing the terms and conditions of the Bromfenac License Agreement dated March 7, 2002, and amended August 13, 2002 and May 31, 2006, this letter is to further document our mutual agreement to the following additional change.

FOURTH AMENDMENT TO BROMFENAC LICENSE AGREEMENT
Bromfenac License Agreement • May 4th, 2012 • Ista Pharmaceuticals Inc • Pharmaceutical preparations

This Fourth Amendment (the “Fourth Amendment”) is made this 26 day of March, 2012 (the “Effective Date”), by and between ISTA Pharmaceuticals, Inc., a Delaware corporation (“ISTA”), and Senju Pharmaceutical Co., Ltd., a legal entity organized and existing under the laws of Japan (“Senju”);

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