Change in Licensed Space Sample Contracts

AMENDMENT NO. 1 CHANGE IN LICENSED SPACE
Change in Licensed Space • October 16th, 2002 • Oragenics Inc

This Amendment No. 1, dated August 16, 2000, is between University of Florida Research Foundation, Inc., a not-for-profit corporation duly organized and existing under the laws of the State of Florida and having its office in 223 Grinter Hall, Gainesville, FL 32611-2037 ("UFRF"), and OraGen, Inc.., a company duly organized under the laws of Florida, and having its principle office at 12085 Research Drive, Alachua, Florida 32615 ("OraGen").

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AMENDMENT NO. 2 CHANGE IN LICENSED SPACE
Change in Licensed Space • October 16th, 2002 • Oragenics Inc

This Amendment No. 2, dated May 13, 2002, is between University of Florida Research Foundation, Inc., a not-for-profit corporation duly organized and existing under the laws of the State Grinter Hall, Gainesville, FL 32611-2037 ("UFRF"), and OraGenics, Inc. organized under the laws of Florida, and having its principle office at 12085 Research Drive, Alachua, Florida 32615 ("OraGen").

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