Collaboration and Facilities Agreement Sample Contracts

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SECOND AMENDMENT TO COLLABORATION AND FACILITIES AGREEMENT
Collaboration and Facilities Agreement • March 22nd, 2006 • Cytokinetics Inc • Pharmaceutical preparations

This SECOND AMENDMENT (“Second Amendment”) is hereby entered into as of January 1, 2006 (the “Second Amendment Effective Date”), by and between Portola Pharmaceuticals, Inc. (“Portola”) and Cytokinetics, Inc. (“Cytokinetics”) (collectively, the “Parties”). Terms used in this Second Amendment and not otherwise defined herein shall have the meanings given to them in the Agreement (as defined below).

FIRST AMENDMENT TO COLLABORATION AND FACILITIES AGREEMENT
Collaboration and Facilities Agreement • May 12th, 2005 • Cytokinetics Inc • Pharmaceutical preparations

This FIRST AMENDMENT (“First Amendment”) is hereby entered into as of March 24, 2005 (the “First Amendment Effective Date”), by and between Portola Pharmaceuticals, Inc. (“Portola”) and Cytokinetics, Inc. (“Cytokinetics”) (collectively, the “Parties”). Terms used in this First Amendment and not otherwise defined herein shall have the meanings given to them in the Agreement (as defined below).

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