AMENDMENT #1 TO COLLABORATION, LICENSE AND DEVELOPMENT AGREEMENTCollaboration, License and Development Agreement • November 5th, 2013 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
This AMENDMENT #1 TO COLLABORATION, LICENSE AND DEVELOPMENT AGREEMENT (this “Amendment”) is entered into as of the date of last signature hereof (the “Amendment Date”) by and between ISIS PHARMACEUTICALS, INC., a Delaware corporation, having its principal place of business at 2855 Gazelle Court, Carlsbad, CA 92010 (“Isis”), and ASTRAZENECA AB, a company incorporated in Sweden under no. 556011-7482 (“AstraZeneca”). Isis and AstraZeneca are each referred to herein by name or as a “Party” or, collectively, as “Parties.”
COLLABORATION, LICENSE AND DEVELOPMENT AGREEMENT BETWEEN ISIS PHARMACEUTICALS, INC., AND ASTRAZENECA ABCollaboration, License and Development Agreement • February 28th, 2013 • Isis Pharmaceuticals Inc • Pharmaceutical preparations • New York
This COLLABORATION, LICENSE AND DEVELOPMENT AGREEMENT (the “Agreement”) is entered into as of the 7th day of December, 2012 (the “Effective Date”) by and between ISIS PHARMACEUTICALS, INC., a Delaware corporation, having its principal place of business at 2855 Gazelle Court, Carlsbad, CA 92010 (“Isis”), and ASTRAZENECA AB, a company incorporated in Sweden under no. 556011-7482 with offices at SE-151 85 Södertälje, Sweden (“AstraZeneca”). AstraZeneca and Isis each may be referred to herein individually as a “Party” or collectively as the “Parties.” Capitalized terms used in this Agreement, whether used in the singular or the plural, have the meaning set forth in APPENDIX 1. All attached appendices and schedules are a part of this Agreement.
AMENDMENT NO.2Collaboration, License and Development Agreement • March 2nd, 2015 • Isis Pharmaceuticals Inc • Pharmaceutical preparations
This Amendment No.2 (“the “Amendment”) to the Collaboration, License and Development Agreement dated December 7th, 2012 (the “Agreement”), is made by and between
AMENDMENT NO. 4Collaboration, License and Development Agreement • March 1st, 2019 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations
This Amendment No. 4 (the “Amendment”) to the Collaboration, License and Development Agreement dated December 7th, 2012 (the “Agreement”), is made by and between
AMENDMENT NO.3Collaboration, License and Development Agreement • May 5th, 2016 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations
This Amendment No.3 (“the “Amendment”) to the Collaboration, License and Development Agreement dated December 7th, 2012 (the “Agreement”), is made by and between
