Issuer Warrant Transaction Agreement Sample Contracts

To: ViroPharma Incorporated 730 Stockton Drive Exton, PA 19341 A/C YMJTD0 From: Credit Suisse International One Cabot Square London E14 4QJ England Subject: Agreement with respect to Issuer Warrant Transaction Reference No. 50302803 Date: March 19, 2009
Issuer Warrant Transaction Agreement • March 24th, 2009 • Viropharma Inc • Pharmaceutical preparations • New York

This letter agreement (this “Agreement”) relates to the Transaction (the “Transaction”) entered into between Credit Suisse International (“Dealer”) represented by Credit Suisse, New York branch (“Agent”) as its agent, and ViroPharma Incorporated (“Counterparty”), pursuant to a letter agreement dated March 20, 2007 entitled Issuer Warrant Transaction (Reference Number: 50302803) (the “Confirmation”). Capitalized terms used herein but not otherwise defined shall have the meanings assigned to them in the Confirmation.

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To: ViroPharma Incorporated 730 Stockton Drive Exton, PA 19341 A/C 4375-691755 From: Wells Fargo Bank, National Association Subject: Agreement with respect to Issuer Warrant Transaction Reference No. OTC032307202-204C Date: March 19, 2009
Issuer Warrant Transaction Agreement • March 24th, 2009 • Viropharma Inc • Pharmaceutical preparations • New York

This letter agreement (this “Agreement”) relates to the Transaction (the “Transaction”) entered into between Wells Fargo Bank, National Association (“Dealer”) and ViroPharma Incorporated (“Counterparty”), pursuant to a letter agreement dated March 20, 2007 entitled Issuer Warrant Transaction (Transaction Reference Number: OTC032307202-204C) (the “Confirmation”). Capitalized terms used herein but not otherwise defined shall have the meanings assigned to them in the Confirmation.

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